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By Robert Plomin

For over 4 many years, Behavioral Genetics has explored the crossroads the place psychology and genetics meet, advancing step-by-step with this dynamic quarter of analysis as new discoveries emerge. the recent 6th version takes its position because the clearest, most recent evaluation of human and animal behavioral genetics on hand, introducing scholars to the field’s underlying ideas, defining experiments, contemporary advances, and ongoing controversies.

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Normal Huntington alleles contain between 11 and 34 copies of the triplet repeat, but Huntington alleles have more than 40 copies. The expanded number of triplet repeats is unstable and can increase in subsequent generations. This phenomenon explains a previously mysteri­ ous non-Mendelian process called g en e tic anticipation, in which symptoms appear at an earlier age and with greater severity in successive generations. For Huntington disease, longer expansions lead to earlier onset of the disorder and greater severity.

The other two w ill carry A, with Bx and A2 with B2. For the latter two pairs, recombination has taken place— these combinations were not present on the parental chromosomes. The probability of recombination between two loci on the same chromosome is a function of the distance between them. 7, for example, the A and C loci have not recombined. All gametes are either A1C1 or A2C2, as in the parents, because the crossover did not occur between these loci. Crossover could occur between the A and C loci, but it would happen less frequently than between A and B.

50% HD 50% Unaffected of inheritance explains why HD individuals always have a parent with HD and why 50 percent of the offspring of an HD parent develop the disease. Why does this lethal condition persist in the population? If HD had its effect early in life, HD individuals would not live to reproduce. In one generation, HD would no longer exist because any individual with the HD allele would not live long enough to reproduce. The dominant allele for HD is maintained from one generation to the next because its lethal effect is not expressed until after the re­ productive years.

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