Download Brain development : relationship to dietary lipid and lipid by Jacqueline Jumpsen PDF

By Jacqueline Jumpsen

'This book's goal is to supply a concentrated assessment (morphological, biochemical and practical) of mind improvement and to exemplify the position of lipids within the very important developmental occasions and the options which are in all likelihood altered via physiological adjustments in mind lipid composition. person chapters comprise: mind development and vulnerability; mind lipids; Lipids and crucial fatty acids in mind improvement; crucial fatty acid synthesis and shipping to the mind; influence of vitamin on fatty acid composition in mind; Glycolipids and gangliosides; Neurotransmitters; and Relevance, reflections and destiny directions.'

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Thromboxanes and prostaglandins are produced via the cyclooxygenase pathway (Fig. 3) and are known to cause vasoconstriction and platelet aggregation. The prostacyclins (PGI2) antagonize these effects. Variations in the ratios of prostaglandin D2:prostaglandin E2:prostaglandin F2α produced by exogenous arachidonate occur between organs and between species. Leukotrienes are produced via the lipoxygenase pathway (Leaf and Copyright © 1995 AOCS Press Weber, 1988) (Fig. 3) and play a role in constriction of bronchial airway musculature, in vascular permeability, and in interactions between the endothelium and white cell population.

Clandinin et al. (1980a) reported that 80% of brain 22:6n-3 accrues in human infants between 26 and 40 weeks of gestation. These authors also observed that infants born prior to 32 weeks gestation have low concentrations of brain 22:6n-3. Earlier in pregnancy, there is apparently a greater dependence on maternal fatty acids to provide the fetus with lipids. This may have important implications for the low birth-weight, premature infant Infant Feeding The main energy source of newborn infants, vital for normal growth and development, is fat.

The tendency exists for medium-chain-length fatty acids to be used for energy, whereas the longer-chain saturated and monounsaturated fatty acids tend to be used for storage. This process may occur indirectly, via the liver, or directly. The liver possesses two well-defined systems for the active chain elongation of fatty acids: the mitochondrial system and the endoplasmic reticulum system. The mitochondrial system utilizes acetyl CoA in the presence of NADH and NADPH to elongate acyl-CoA derivatives.

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