By Gary C. Rosenfeld Ph.D., David S. Loose PhD
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Extra info for BRS Pharmacology
Eye (1) Direct-acting muscarinic cholinoceptor agonists contract the circular smooth muscle fibers of the ciliary muscle and iris to produce, respectively, a spasm of accommodation and an increased outflow of aqueous humor into the canal of Schlemm, resulting in a reduction in intraocular pressure. (2) These drugs contract the smooth muscle of the iris sphincter to cause miosis. b. Cardiovascular system (1) Direct-acting muscarinic cholinoceptor agonists produce a negative chronotropic effect (reduced SA node activity).
16. The answer is A. The initial rate of distribution of a drug to a tissue depends primarily on the rate of blood flow to that tissue. , a very lipophilic drug may become concentrated in adipose tissue with time. 17. The answer is B. The induction of the cytochrome P-450 following chronic administration will increase the conversion of the inactive prodrug to the active form. , increase its potency) without changing its efficacy. 18. The answer is C. The CYP3A subfamily is responsible for roughly 50% of the total cytochrome P450 activity present in the liver and is estimated to be responsible for approximately half of all clinically important untoward drug interactions resulting from metabolism.
Highly organized, semiautonomous, neural complex localized in the gastrointestinal (GI) system. c. Receives preganglionic axons from the PNS and postganglionic axons from the SNS. d. Nerve terminals contain peptides and purines as neurotransmitters. B. The somatic nervous system (Fig. 1) controls voluntary activity. This system contains long axons that originate in the spinal cord and directly innervate skeletal striated muscle. C. Neurotransmitters of the autonomic and somatic nervous systems (Fig.