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By G. Obe (Editor), A. T. Natarajan (Editor)

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Extra info for Chromosome Aberrations (Reprint of Cytogenetic and Genome Research 2004)

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Genetics 139:45–56 (1995). Reiss B, Schubert IS, Köpchen K, Wendeler E, Schell J, Puchta H: RecA stimulates sister chromatid exchange and the fidelity of double-strand break repair, but not gene targeting, in plants transformed by Agrobacterium. Proc natl Acad Sci USA 97:3358–3363 (2000). Sargent RG, Meservy JL, Perkins BD, Kilburn AE, Intody Z, Adair GM, Nairn RS, Wilson JH: Role of the nucleotide excision repair gene ERCC1 in formation of recombination-dependent rearrangements in mammalian cells.

The blots were sequentially probed with 32P-labeled Alu, or B2, to preferentially illuminate R-band DNA, by L1 to preferentially illuminate G-band DNA, and by satellite DNA to illuminate C-band DNA. These three different DNA populations showed slightly different global nucleotide excision repair rates that are in the order of speed, R-band DNA 1 G-band DNA 1 C-band DNA. Fibroblasts from outbred neonatal mice and humans showed similar band-specific repair rate ratios and the global repair rate of murine fibroblasts was almost as rapid as that of the human fibroblasts.

2003). They showed that the repair by HR of I-SceIinduced DSBs was severely suppressed in FancG-knockout DT40 cells. , 1975) and variable among patients (Kano and Fujiwara, 1981; Sasaki, 1982). In our earlier studies, a patient FA17JTO showed a somewhat elevated SCE response to MMC, but another patient FA20JTO showed a below normal response (Kano and Fujiwara, 1981; Sasaki, 1982). , 1999, and their unpublished data). , 2003), indicating that the net-induced frequencies are rather reduced in the MMCtreated mutant cells.

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