By A. J. Shatkin, A. K. Banerjee, G. W. Both (auth.), Heinz Fraenkel-Conrat, Robert R. Wagner (eds.)
The time turns out ripe for a serious compendium of that phase of the organic universe we name viruses. Virology, as a technological know-how, having handed only in the near past via its descriptive section of naming and num bering, has most likely reached that level at which fairly few new actually new-viruses could be stumbled on. caused through the highbrow probes and strategies of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the sphere has skilled a real info explosion. Few severe makes an attempt were made to chronicle those occasions. This entire sequence, in an effort to include a few 6000 pages in a complete of approximately 22 volumes, represents a dedication via a wide team of energetic investigators to research, digest, and expostulate at the nice mass of knowledge when it comes to viruses, a lot of that is now amorphous and disjointed, and scattered all through a large literature. during this method, we are hoping to put the complete box in viewpoint, and to advance a useful reference and sourcebook for researchers and scholars in any respect degrees. This sequence is designed as a continuum that may be entered wherever, yet which additionally presents a logical development of constructing proof and built-in concepts.
Read or Download Comprehensive Virology 10: Regulation and Genetics Viral Gene Expression and Integration PDF
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Additional info for Comprehensive Virology 10: Regulation and Genetics Viral Gene Expression and Integration
2. 2a. 5 52 40 29 372 372 33 33 (L) 195 2000 206 P63 N NS II III a RNA species Proteins coded Proteins Molecular weights of proteins were calculated using as marlttn myosin, unreduced rabbit ,),-globulin, Escherichia coli /'1-galactosidase, bovine serum albumin, ovalbumin, and a-chymotrypsinogen with molecular weights of 200,000, 150,000, 130,000, 68,000, 45,000, and 25,000, respectively. The molecular weight of viral G protein was estimated to be 66,000 from these values. , 1974). The L protein has not been translated from 31 S RNA synthesized in vitro.
1975). By incubating the viral DNA with E. coli RNA polymerase followed by the addition of wheat germ protein-synthesizing extract, an eightyfold stimulation in [3 5S]methionine incorporation into acid-precipitable products was obtained. Protein synthesis was dependent on the formation, during the transcription step, of mRNA which was heterogeneous in size (4-26 S). The polypeptide products directed by the mRNA included a protein of molecular weight 48K that was specifically precipitated with antiserum against disrupted virions and yielded a tryptic peptide map almost identical to that of SV40 VPl.
Smith, S. T. Bayley, T. Wheeler, and W. F. Mangel (personal communication), using cRNA-stimulated wheat germ extract, have also detected the synthesis of a 59K polypeptide that reacted specifically with hamster anti-T serum. This finding suggests the exciting possibility that T antigen can be synthesized in vitro in a coupled system. , 1975). Cleavage of supercoiled viral DNA form I to the linear duplex form III by restriction nucleases EeoRI and Baml (from Bacillus amyioliquejaeiens H) did not inactivate its template activity for VP1 synthesis in the coupled in vitro system.