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Extra resources for Constrained Minimization of smooth function using a genetic algoritm
2. SURVIVAL ANALYSIS METHODS FOR AGGREGATION ANALYSIS The purpose of aggregation analysis is to test whether disease aggregates within a family after some known environmental risk factors are taken into account. The ideal design is to collect a random sample of N families from the study population and to collect both age of disease onset or age at censoring data and the environmental risk factors of all the individuals within the families sampled. Then, the test of disease aggregation within the family will be equivalent to testing whether the ages of onset of family members are correlated after adjusting for environmental risk factors.
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